Product Type: Ligand
CAS No.: 474-73-7
MolecularFormula: C27H46O2
Molecular Weight: 402,7
Source: Synthetic
Purity: >98%
Solubility: Soluble in ethanol (10 mg/ml) or DMSO (10 mg/ml - requires warming up to ~40°C).
Appearance: White solid
PubChem CID: 121948
Scientific Background: Endogenous agonist for the nuclear receptor LXR. Important metabolite of cholesterol in the brain. Displays neurotoxic effects on human neuroblastoma cells. Cerebrospinal fluid concentrations of 24(S)-hydroxycholesterol are increased in patients with Alzheimer's disease and mild cognitive impairment.
References: 1. Chawla A., et al. (2001) Science. 294(5548): 1866-70.2. Lütjohann D., et al. (1996) Proc. Natl. Acad. Sci. USA. 93(18): 9799-804.3. Kölsch H., et al. (1999) Brain Res. 818(1): 171-5.4. Schönknecht P., et al. (2002) Neurosci. Lett. 324(1): 83-5.5. Leoni V., et al. (2006) Neurosci. Lett. 397(1-2): 83-7.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.