24(S)-Hydroxycholesterol, CAS 474-73-7

LXR ligand

Product Type: Ligand

CAS No.: 474-73-7

MolecularFormula: C27H46O2

Molecular Weight: 402,7

Source: Synthetic

Purity: >98%

Solubility: Soluble in ethanol (10 mg/ml) or DMSO (10 mg/ml - requires warming up to ~40°C).

Appearance: White solid

PubChem CID: 121948

Scientific Background: Endogenous agonist for the nuclear receptor LXR. Important metabolite of cholesterol in the brain. Displays neurotoxic effects on human neuroblastoma cells. Cerebrospinal fluid concentrations of 24(S)-hydroxycholesterol are increased in patients with Alzheimer's disease and mild cognitive impairment.

References: 1. Chawla A., et al. (2001) Science. 294(5548): 1866-70.2. Lütjohann D., et al. (1996) Proc. Natl. Acad. Sci. USA. 93(18): 9799-804.3. Kölsch H., et al. (1999) Brain Res. 818(1): 171-5.4. Schönknecht P., et al. (2002) Neurosci. Lett. 324(1): 83-5.5. Leoni V., et al. (2006) Neurosci. Lett. 397(1-2): 83-7.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-384-5MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-384-5MG
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK