3-aminobenzamide , CAS 3544-24-9

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Background: 3-aminobenzamide can sensitize cells to radiation in vitro by inhibiting the repair of DNA damage, presumably via PARP inhibition. 3-aminobenzamide is currently in phase 2 clinical trials and has shown positive effects for stroke, myocardial infarction, GI tract inflammation, and diabetic endothelial dysfunction.

Biological Activity: 3-aminobenzamide is a novel potent PARP inhibitor with an IC50 of ~30 µM. Exhibits IC50 of < 50 nM in CHO cells.

CAS Number: 3544-24-9

Description: 3-aminobenzamide is a novel, potent inhibitor of PARP. Also acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.

Purity: ≥98% by HPLC

Solubility: Soluble in DMSO (30 mg/ml) and water (25 mg/ml)

Storage Stability: Store at room temperature. Solid form is stable at least 12 months from date of receipt, when stored as directed. DMSO stock solutions should be stored in aliquots at -20°C for up to 1 month.  Do not store aqueous solutions for more than one day.

Biosafety Level: Not applicable (BSL-1)

References: 1. Ferraris D.V., J of Med Chem, 2010, 53, 4561-4584

• Artikelnummer: BPS79888-2
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 79888-2
• Verpackungseinheit: 1 g
• Mengeneinheit: STK