4-Hydroxynonenal Antibody, Clone 12F7: ATTO 390

Mouse Anti-4-Hydroxynonenal (4-HNE) Monoclonal IgG1

Target: 4-Hydroxynonenal

Conjugate: ATTO 390

Product Type: Monoclonal

Clone Number: 12F7

Immunogen: Synthetic 4-Hydroxynonenal modified Keyhole Limpet Hemocyanin (KLH).

Purification: Protein G Purified

Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Specific for 4-Hydroxynonenal (4-HNE) modified proteins. Does not detect free 4-Hydroxynonenal. Does not cross-react with 4-Hydroxy-2-hexenal, Acrolein, Crotonaldehyde, Hexanoyl Lysine, Malondialdehyde, or Methylglyoxal modified proteins.

Scientific Background: 4-Hydroxy-2-nonenol (4-HNE) is an unsaturated aldehyde derived from lipid peroxidation. 4-HNE is an electrophile and reacts with protein nucleophiles such as cysteine, histine, and lysine (1). Low levels of 4-HNE promote cell survival via cellular antioxidant induction whereas higher levels lead to autophagy, apoptosis, and ultimately necrosis. 4-HNE has been linked to Alzheimer's disease, Parkinson's disease, cancer, cardiovascular diseases, diabetes, and liver disease.

References: 1. Peterson, D., Doorn, J. (2004) Free Radic Biol Med. 37(7):937-945.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-511D-A390
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-511D-A390
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Various species
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, ELISA, Immunocytochemistry
• Isotyp: IgG1
• Wirt: Mouse