5,7,3',4',5'-Pentamethoxyflavone, CAS 53350-26-8

Formulation: A solid

Formal Name: 5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Formula Markup: C20H20O7

Formula Weight: 372,4

Shelf life (days): 1460

CAS Number: 53350-26-8

Notes: 5,7,3',4',5'-Pentamethoxyflavone is a flavonoid that has been found in M. paniculata and has diverse biological activities.{72145,72146,72147,72148} It inhibits pancreatic lipase in a cell-free assay and reduces lipid accumulation in 3T3-L1 adipocytes in a concentration-dependent manner.{72145} 5,7,3',4',5'-Pentamethoxyflavone inhibits transactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) in a reporter assay using HEK293T cells when used at concentrations of 10, 25, or 50 µM.{72146} It inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages and GES-1 cells.{72147} 5,7,3',4',5'-Pentamethoxyflavone (25 µM) sensitizes cisplatin-resistant A549 non-small cell lung cancer (NSCLC) cells to the DNA-crosslinking agent cisplatin (Item No. 13119).{72146} In vivo, 5,7,3',4',5'-pentamethoxyflavone (5 mg/kg) decreases blood glucose levels and renal fibrosis in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).{72148}

• Artikelnummer: CAY39820-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39820-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK