5-Lipoxygenase antibody (GT1241)

Clone Name: GT1241

Application Note: WB: 1:500 - 1:2000. ICC/IF: 1:50 - 1:200. IHC-P: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 78

Form: Liquid

Buffer (with preservative): PBS, 0.05% BSA, 50% Glycerol, 0.02% Sodium azide.

Concentration: 1.45 mg/ml (Please refer to the vial label for the specific concentration.)

Background: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot ID: P09917

Antigen Species: Human

Immunogen: A synthesized peptide derived from human ALOX5

Purification: Purified by antigen-affinity chromatography

Conjugation: Unconjugated

Full Name: arachidonate 5-lipoxygenase

• Artikelnummer: GTX02838-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX02838-100
• Green Labware: Nein
• Verpackungseinheit: 100 μl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunohistochemistry (paraffin), Western Blotting, Immunocytochemistry
• Isotyp: IgG
• Human Gene ID: 240
• Wirt: Rabbit