Product Type: Ligand
CAS No.: 172922-91-7
MolecularFormula: C19H12N2O
Molecular Weight: 284,3
Source: Synthetic
Purity: >95%
Solubility: Soluble in DMSO (10 mg/ml)
Appearance: Yellow solid
PubChem CID: 22245026
Scientific Background: A tryptophan-derived, high affinity aryl hydrocarbon receptor ligand (Kd=7x10-11 M). Proposed to be an endogenous AhR ligand. Induces rapid and transient expression of cytochrome P450-1A1 (CYP1A1) in human cells at 100 pM.
References: 1. Wei Y.D., et al. (1998) Chem. Biol. Interact. 110(1-2): 39-55. 2. Rannug U., et al. (1995) Chem. Biol. Drug. Des. 2(12): 841-855.3. Rannug A., et al. (1987) J. Biol. Chem. 262(32): 15422-7.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.