Product Description: α-Conotoxin Im-I is a selective α7/α9 nAChR antagonist, blocking α7 nicotinic receptors with the highest apparent affinity, while having an 8-fold lower affinity for homomeric α9 nicotinic receptors. α-Conotoxin Im-I is toxic and induces seizures in rodents. α-Conotoxin Im-I is a tool for studying neuronal nAChR[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C52H78N20O15S4
References: [1]Johnson DS, et al. alpha-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric alpha 7 and alpha 9 receptors. /[2]Quiram P A, et al. Pairwise interactions between neuronal α7acetylcholine receptors and α-conotoxin PnIB. Journal of Biological Chemistry, 2000, 275(7): 4889-4896.
CAS Number: 156467-85-5
Molecular Weight: 1351.56
Compound Purity: 98.15
Research Area: Neurological Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: nAChR