(−)-α-Thujone, CAS 546-80-5

Formulation: A liquid

Formal Name: (1S,4R,5R)-4-methyl-1-(1-methylethyl)-bicyclo[3.1.0]hexan-3-one

Purity: ≥95%

Formula Markup: C10H16O

Formula Weight: 152,2

Shelf life (days): 1460

CAS Number: 546-80-5

Notes: (–)-α-Thujone is a monoterpene ketone and a major component of absinthe and has diverse biological activities.{67513,67512,67514,67515} It inhibits currents induced by acetylcholine (ACh) in Xenopus oocytes expressing human α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 27 µM).{67513} (–)-α-Thujone (100 and 300 µM) reduces GABA-induced current amplitude in HEK293 cells expressing α1β2δ subunit-containing GABA receptors.{67512} It reduces levels of the Norovirus surrogates feline calcivirus-F9 (FCV-F9) and murine norovirus 1 (MNV-1) in a plaque formation assay when used at a concentration of 25 mM.{67514} In vivo, (–)-α-thujone (1.25 mg/kg, i.p.) impairs nicotine-induced enhancement of long-term potentiation in the dentate gyrus, a marker of learning and memory, in rats.{67513} It also inhibits lung metastasis and increases survival in a B16/F10 murine melanoma model when administered at a dose of 1 mg/kg.{67515}

• Artikelnummer: CAY39792-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39792-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK