Acrolein Antibody, Clone 2H2: APC

Mouse Anti-Acrolein conjugated protein Monoclonal IgG1

Target: Acrolein

Conjugate: APC

Product Type: Monoclonal

Clone Number: 2H2

Immunogen: Synthetic Acrolein modified Keyhole Limpet Hemocyanin (KLH).

Purification: Protein G Purified

Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Specific for Acrolein modified proteins. Does not detect free acrolein. Does not cross-react with Crotonaldehyde, Hexanoyl Lysine, 4-Hydroxy-2-hexenal, 4-Hydroxy nonenal, Malondialdehyde, or Methylglyoxal modified proteins.

Scientific Background: Lipid peroxidation occurs when oxidizing agents attack carbon-carbon double bonds found in unsaturated lipids. In addition to membrane degradation, oxidation end-products have been found to damage cell viability through their mutagenic and toxic properties. These downstream functional consequences facilitate the development of disease and premature aging. Acrolein is an electrophilic conjugated aldehyde that is a terminal product of lipid peroxidation. Acrolein is highly mutagenic and reacts with nucleophilic functional groups in DNA and proteins such as cysteine, histidine, and lysine residues (1).

References: 1. Takabe, W. et al. (2001) Carcinogenesis. 22 (6): 935-952

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-504D-APC
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-504D-APC
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Various species
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, ELISA, Flow Cytometry, Immunocytochemistry, Fluorescence-Activated Cell Sorting (FACS)
• Isotyp: IgG1
• Wirt: Mouse