Scientific Background: The actinomycins are a class of polypeptide antibiotics. Actinomycin D inhibits transcription by binding DNA at the transcription initiation complex and preventing elongation by RNA polymerase (1). Actinomycin D has been used as a chemotherapy drug (2), and an antibiotic.
References: 1. Sobell H. (1985) Proc Natl Acad Sci USA. 82(16): 5328-31.2. Turan T., et al. (2006) Int J Gynecol Cancer. 16(3): 1432-1438.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.