Beta Synuclein Pre-formed Fibrils (Type 1)

Human Recombinant Beta Synuclein Protein Pre-formed Fibrils (Type 1)

Target: Beta Synuclein.

Nature: Recombinant.

Swiss-Prot: Q16143.

Expression System: E. coli.

Protein Length: Full length.

Purification: Ion-exchange Purified.

Purity: >95%.

Storage Buffer: PBS pH 7.4.

Protein Size: 14.28 kDa.

Conjugate: No tag.

Cellular Localization: Cytoplasm.

Scientific Background: Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Beta synuclein is abundant in neurofibrillary lesions of patients with Alzheimer's Disease. Beta synuclein is suggested to be an inhibitor of alpha synuclein aggregation- protecting the central nervous system from the neurotoxin effects of alpha synuclein (3).

References: 1. www.alz.org/alzheimers-dementia/facts-figures2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907). 3. Taschenberger G., et al. (2013) Ann Neurol. 74(1): 109-118.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.

• Artikelnummer: STRSPR-457E
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SPR-457E
• Green Labware: Nein
• Verpackungseinheit: 100 µg x5
• Mengeneinheit: PAK
• Reaktivität: Human
• Methode: Western Blotting, In Vivo Assay, SDS-PAGE
• Human Gene ID: 6620