ADAMTS4 Polyclonal Antibody, Rabbit

ADAMTS4 Polyclonal Antibody, Rabbit
Artikelnummer
ELSE-AB-93370-60
Verpackungseinheit
60 µl
Hersteller
Elabscience Biotechnology

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Abbreviation: ADAMTS4

Target Synonym: ADAMTS4;ADAMTS-2;ADAMTS-4;ADMP-1

Conjugation: Unconjugated

UNIProt ID: O75173

Background: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human ADAMTS4

Dilution: IF 1:50-1:200
Mehr Informationen
Artikelnummer ELSE-AB-93370-60
Hersteller Elabscience Biotechnology
Hersteller Artikelnummer ELA-E-AB-93370-60
Green Labware Nein
Verpackungseinheit 60 µl
Mengeneinheit STK
Reaktivität Human, Mouse (Murine), Rat (Rattus)
Klonalität Polyclonal
Methode Immunofluorescence
Isotyp IgG
Wirt Rabbit
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