AG 1478, CAS 153436-53-4

EGFR kinase inhibitor

Product Type: Inhibitor

CAS No.: 153436-53-4

MolecularFormula: C16H14ClN3O2

Molecular Weight: 315,8

Source: Synthetic

Purity: ≥98% (HPLC)

Solubility: Soluble in DMSO (10 mg/ml)

Appearance: White to light yellow solid

PubChem CID: 2051

Scientific Background: AG 1478 is a potent and selective inhibitor of EGFR. It does so by reducing EGF-stimulated DNA synthesis (seen in rat fibroblasts) and blocking EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction (seen in A431 cells). AG 1478 is cell-permeable and active in vivo.

References: 1. Osherov N., & Levitzki A. (1994) Euro J. Biochem. 225(3): 1047–1053.2. Miyazaki Y., et al. (1996) Biochem. Biophys. Research Comm. 226(2): 542–546. 3. Fan Z., et al. (1995) J Cell Biol. 131(1): 235–242.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-425-25MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-425-25MG
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK