(Ala11,D-Leu15)-Orexin B (acetate)

Shelf life (days): 1460.0

Formulation: A crystalline solid

Amino Acids: RSGPPGLQGRAQRLXQASGNHAAGILTM-NH2 (X = D-Leucine)

Purity: ≥98%

Formula Markup: C120H206N44O35S / XC2H4O2

Formula Weight: 2857.2612

Notes: [Ala11,D-Leu15]-Orexin B is a synthetic peptide agonist of the orexin 2 (OX2) receptor.{68451} It selectively induces calcium mobilization in CHO-K1 cells expressing OX2 over CHO-K1 cells expressing OX1 (EC50s = 0.13 and 52 nM, respectively, for the human receptors). [Ala11,D-Leu15]-Orexin B inhibits forskolin-, PACAP (1-27)-, or VIP-induced cAMP formation in primary rat neuronal cells (IC50s = 42, 32.3, and 22.9 nM, respectively).{28459} It increases mean arterial pressure (MAP), heart rate, and phrenic nerve activity in rats when intracranially administered at a dose of 0.75 pmol/animal.{68452}

• Artikelnummer: CAY36728-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36728-500
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK