alpha Synuclein antibody (5C2)

Clone Name: 5C2

Light Chain: Kappa

Application Note: WB: 1:500-1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 14

Specificity/Sensitivity: Based on internal testing result, this antibody does not cross react with human beta- and gamma-synuclein.This antibody specifically recognizes the NAC domain (61-95aa) of alpha-synuclein.

Form: Liquid

Buffer (with preservative): PBS, 10% Glycerol, 0.02% Sodium azide.

Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)

Background: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]

Uniprot ID: P37840

Antigen Species: Human

Immunogen: The clone 5C2 is derived from hybridization of mouse SP2/2 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human alpha-synuclein protein.

Purification: Protein G Purified

Conjugation: Unconjugated

Full Name: synuclein alpha

• Artikelnummer: GTX57554-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX57554-100
• Green Labware: Nein
• Verpackungseinheit: 100 μl
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Western Blotting
• Isotyp: IgG1
• Human Gene ID: 6622
• Wirt: Mouse