Alsterpaullone, CAS 237430-03-4

CDK, GSK Inhibitor

Product Type: Inhibitor

CAS No.: 237430-03-4

MolecularFormula: C16H11N3O3

Molecular Weight: 293,3

Source: Synthetic

Purity: ≥98% (HPLC)

Solubility: Soluble in DMSO; insoluble in water or 100% ethanol

Appearance: Yellow to brown powder

PubChem CID: 5005498

Scientific Background: Alsterpaullone is a potent inhibitor of CDK1/cyclin B. It is also a potent and selective inhibitor of GSK-3β and CDK5/p25. Alsterpaullone induces apoptosis by activating caspase-8 and caspase-9, followed by disruption of the mitochondrial potential. It is cell-permeable.

References: 1. Zaharevitz D.W., et al. (1999). Cancer Research. 59(11): 2566–2569.2. Lahusen T., De Siervi A., Kunick C., & Senderowicz A.M. (2003) Mol. Carcinogenesis. 36(4): 183–194.3. Schultz C., et al. (1999) J. Med. Chem. 42(15): 2909–2919.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-431-5MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-431-5MG
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK