Product Type: Activator
CAS No.: 20537-88-6
MolecularFormula: C5H15N2O3PS
Molecular Weight: 214,22
Source: Synthetic
Purity: >98%
Solubility: Soluble in water
Appearance: White Solid
PubChem CID: 2141
Scientific Background: Amifostine is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy. Inside cells it detoxifies reactive metabolites of platinum and alkylating agents (1, 2). Other effects include accelerated DNA repair (1), induction of cellular hypoxia (1), inhibition of apoptosis (2), alteration of gene expression (2) and modification of enzyme activity (2).
References: 1. Kouvaris J.R., Kouloulias V.E., Blahos L.J. (2007) Oncologist. 12(6): 738-747.2. Amifostine: BC Cancer Agency. 2006-03-01.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.