Product Type: Inducer
CAS No.: 19774-82-4
MolecularFormula: C25H29I2NO3•HCl
Molecular Weight: 681,77
Source: Synthetic
Purity: >99 %
Solubility: Soluble to 50 mM in DMSO
Appearance: White solid
PubChem CID: 441325
Scientific Background: Amiodarone is a non-selective ion channel blocker. It has been found, when used in Saccharomyces cerevisiae, to induce an influx of Ca2+ followed by mitochondrial fragmentation and subsequent cell death. Amiodarone has also been shown to induce autophagy by inhibiting mTORC1. Lastly, Amiodarone has broad-spectrum fungicidal activity.
References: 1. Zhang Y., et al. (2007). J Biol Chem. 282(52): 37844-53.2. Balgi A., et al. (2009). PLoS One. 4(9): e7124.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.