Amyloid Beta 1-42 Oligomer Antibody, Clone 1C1

Rabbit Anti-Human Amyloid Beta 1-42 Oligomer Recombinant Monoclonal IgG

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Target: Amyloid Beta 1-42 Oligomer

Conjugate: Unconjugated

Product Type: Recombinant Monoclonal

Clone Number: 1C1

Immunogen: Amyloid beta 1-42 oligomers (StressMarq Catalog# SPR-488)

Swiss-Prot: P05067

Purification: Protein A Purified

Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% sodium azide. *Storage buffer may change when conjugated

Concentration: 0.5mg/ml

Specificity: Amyloid Beta 1-42 oligomers

Cellular Localization: Membrane (Secreted)

Tissue Specificity: CNS, Blood

Scientific Background: Our amyloid beta oligomer antibody (clone 1C1) has been tested for specificity against synthetic AB 1-42 aggregates, with higher specificity to oligomers demonstrated. In the brain, amyloid beta peptide (Aβ) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques in neurodegenerative diseases. The accumulation of Aβ plaques in the brain is considered a hallmark of Alzheimer’s disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation (1). The immunogen used was our Amyloid Beta 1-42 (Aβ42) Oligomers are generated from Amyloid Beta Peptide 1-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as previously published (2,3).

References: 1. Panza et al. 2019. Nat Rev Neurol. 15:73-88 https://doi.org/10.1038/s41582-018-0116-62. Stine et al. 2003. JBC. 278(13):11612-22. doi: 10.1074/jbc.M2102072003. Ahmed et al. 2010. Nature Structural & Molecular Biology. 17(5):561 doi: 10.1038/nsmb.1799

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-619S
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-619S
• Verpackungseinheit: 12 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Western Blotting, ELISA
• Isotyp: IgG
• Human Gene ID: 351 (APP)
• Wirt: Rabbit
• Konjugat: Unconjugated