Androgen Receptor antibody (AR27)

Clone Name: AR27

Application Note: IHC-P: 1:25. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 99

Form: Liquid

Buffer (with preservative): Tissue culture supernatant, 0.09% Sodium azide.

Concentration:

Background: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

Uniprot ID: P10275

Antigen Species: Human

Immunogen: Prokaryotic recombinant protein of 321 amino acids representing the N-terminus of the human androgen receptor.

Purification: Unpurified

Conjugation: Unconjugated

Full Name: androgen receptor

• Artikelnummer: GTX01898-500
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX01898-500
• Green Labware: Nein
• Verpackungseinheit: 500 μl
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG1
• Human Gene ID: 367
• Wirt: Mouse