Anti-BubR1/BUB1B Antibody Picoband™ (monoclonal, 8B3)

Clone Number: 8B3

Immunogen: E.coli-derived human BubR1/BUB1B recombinant protein (Position: K26-E448).

Concentration: Adding 0.2 ml of distilled water =f 500 μg/ml.

Format: Lyophilized

Storage buffer: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Additional info: Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.Add 0.2ml of distilled water will yield a concentration of 500ug/ml. Background: Mitotic checkpoint serine/threonine-protein kinase BUB1 betais anenzymethat in humans is encoded by theBUB1Bgene. This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. Subcellular Localization: Centrosome. Nucleus. Cytoplasm. Kinetochore. Tissue Specificity: Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index.

• Artikelnummer: SANMON23721
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON23721
• Green Labware: Nein
• Verpackungseinheit: 100μg
• Mengeneinheit: STK
• Reaktivität: Human, Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Western Blotting, Flow Cytometry, Immunohistochemistry
• Isotyp: IgG2b
• Wirt: Mouse