Anti-CD4 Antibody, Biotin-Labeled

Products from BPS Bioscience require a minimum order value above 400€

Applications: Useful for studying the binding to CD4 in ELISA

Background: CD4 (cluster of differentiation 4) is part of the immunoglobulin superfamily, and it can be found in T-helper cells, monocytes, macrophages and dendritic cells. It is a co-receptor in the TCR (T-cell receptor), binding to MHC (major histocompatibility complex) class II molecules. CD4 binds to the tyrosine kinase Lck (lymphocyte-specific protein tyrosine kinase), which can phosphorylate the ITAM (immunoreceptor tyrosine activation motifs) domain of the CD3, activating CD3 related signaling. CD4 is a typical T cell marker of T helper cells, and it has been linked to cancer, autoimmune diseases such as vitiligo and type I diabetes. In addition, HIV-1 makes use of CD4 to trigger viral envelope protein conformational changes that allow cell infection. Ibalizumab, an anti-CD4 antibody, is currently used in the treatment of HIV, being considered a first-in-class medication. Further studies into CD4 and potential strategies around it may benefit patients and CD4 related diseases.  

Description: This purified recombinant antibody is a humanized mouse IgG4κ anti-CD4 (cluster of differentiation 4) antibody that selectively binds to CD4. Its sequence is similar to Ibalizumab. This antibody has a C-terminal Avi-Tag™ on its heavy chain. This antibody has been tested for specific binding to human CD4 in an in vitro ELISA. 

Format: Aqueous buffer solution.

Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

Host Cell Line: HEK293

Purity: ≥90%

Storage Stability: At least 6 months at -80°C.

Uniprot: P06332

Warnings: Avoid freeze/thaw cycles

Biosafety Level: Not applicable (BSL-1)

• Artikelnummer: BPS101761-2
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 101761-2
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Klonalität: Monoclonal
• Methode: ELISA
• Wirt: Human