Products from BPS Bioscience require a minimum order value above 400€
Application: Useful for studying the expression of human CDH17 on the cell surface by flow cytometry.
Background: CHD17 (cadherin 17), also known as LI (liver-intestine)-cadherin, is a unique member of the cadherin superfamily of proteins, as it has seven instead of the five typical cadherin domains. It is a calcium-dependent membrane-associated glycoprotein normally expressed on epithelial cells of the small intestine and colon, where it regulates intercellular adhesion. Upregulation of this protein is found in gastric cancer, colorectal and pancreatic cancer, amongst others. CHD17 has become a therapeutic target of interest, with studies using monoclonal antibodies, ADC (antibody drug conjugates) and CAR (chimeric antigen receptor)-T cells resulting in promising outcomes.
Cross Reactivity: This antibody recognizes human CDH17. It has not been tested in other species.
Description: This anti-CDH17 (cadherin-17) antibody is a purified monospecific recombinant antibody, which is labeled with R-Phycoerythrin (PE). This antibody has been tested by flow cytometry for binding to human Cadherin-17 (CDH17) on the surface of HCT116 cells.
Format: Aqueous buffer solution.
Formulation: 8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 0.09% Sodium Azide, 0.2% BSA, and up to 20% glycerol. May contain a protein stabilizer.
Purification: Protein A affinity chromatography from HEK293 supernatants.
Purity: ≥90%
Storage Stability: At least 6 months at +4°C. Protect from prolonged exposure to light. DO NOT FREEZE. The antibody solution should be stored undiluted between +2°C and +8°C.
Uniprot: Q12864
Warnings: Do not freeze. Protect from light.
Biosafety Level: Not applicable (BSL-1)
Deutsch
English
