CloneID: 2C6.9
Heavy Chain modification: Fc Silent™
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human scFv format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P56856
Specificity Statement: This antibody is specific for human claudin-18.2. Alterations in claudin expression can impair tight junction function, influence signaling pathways, and act as a tumor-promoting event in some epithelial cancers. Claudin 18.2 is overexpressed in various tumor type and is found to be a potentially important target in advanced gastric cancer.
Application Notes (Clone): This antibody can be used for the detection of human claudin 18.2. This antibody was also used in the generation of a CAR-T cell receptor. CLDN18.2 CAR-T specifically binds to tumor cells, activated 2C6.9-T-PD-1 CAR-T alleviates or eliminates immunosuppression by secreting anti-PD-1 antibodies, increasing the anti-tumor effect. 2C6.9-T can activate primary T cells and efficiently mediate the killing of tumor cells expressing CLDN18.2 by T cells and caused a significant increase in cytokine secretion (CN113754780).
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