CloneID: AT12-015
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was obtained from supernatants of B cell cultures that were screened for binding to HPeV3 infected monolayers of Vero cells
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human Fab format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: Q8BES5
Specificity Statement: This antibody is specific for Human parechovirus 3 strain A308/99.
Application Notes (Clone): The structure of the original antibody was determined using cryo-EM. This antibody was used for a neutralization assay on human HT29 cells with HPeV3 as infectant (Domanska et al., 2019; PMID:30463974), on Vero cells with HPeV3 as infectant (Shakeel et al., 2016; PMID:27435188), and on LLCMK2 cells with HPeV3 as infectant. This antibody was used for immunofluorescence on HT29 cells infected with HPeV3 (Kareletho et al., 2017; PMID:28935894).
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