CloneID: CNTO 1275 (Ustekinumab)
Antigen Long Description: The original antibody was produced by immunizing human immunoglobulin transgenic mice ((CBA/J×C57/BL6/J) F2 hybrid) with human recombinant IL-12.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: This antibody is specific for the p40 subunit of human IL-12/23.
Application Notes (Clone): This antibody inhibits the interactions of IL-12 and IL-23 with the cell surface IL-12Rβ1 receptor and has been evaluated in phase I, II, and III trials as a treatment for immune-mediated diseases such as psoriasis, psoriatic arthritis, Crohn’s disease, multiple sclerosis, and ulcerative colitis (Elliott et al., 2009; PMID: 20074279) (Sands et al., 2019; PMID: 31553833).
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