Anti-MAdCAM-1 (MECA-89)

Anti-MAdCAM-1 [MECA-89], Recombinant, IgG kappa, Rabbit
Artikelnummer
ABAAb03850-23.0
Verpackungseinheit
100 μg
Hersteller
Absolute Antibody

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CloneID: MECA-89

Antigen Long Description: Endothelial cells isolated from BALB/c mouse mesenteric and peripheral lymph nodes.

Buffer Composition: PBS with 0.02% Proclin 300.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Specificity Statement: The antibody is specific for mouse MAdCAM-1. The antibody recognizes the second immunoglobulin domain, interfering with L-selectin interactions of MAdCAM-1. The mucosal lymphocyte homing receptor MAdCAM-1 is expressed in the high endothelial venules of the mesenteric lymph nodes (MLN) and Peyer's patches (PP) and in the flat epithelium of the lamina propria (LP).

Application Notes (Clone): The antibody bound to the second domain of MAdCAM-1 and did not block MAdCAM-1-dependent binding in vitro (Streeter et al., 1988; PMID:3340147). The antibody was used for immunohistochemical analysis of healthy AKR control mice and it showed faint basal expression of MAdCAM-1 in the terminal ileum (Bachmann et al. 2006). The antibody blocked interactions with L-selectin in vivo (Bargatze et al., 1995; PMID: 7542550).
Mehr Informationen
Artikelnummer ABAAb03850-23.0
Hersteller Absolute Antibody
Hersteller Artikelnummer Ab03850-23.0
Verpackungseinheit 100 μg
Mengeneinheit STK
Reaktivität Mouse (Murine)
Klonalität Recombinant
Methode Immunohistochemistry, Blocking
Isotyp IgG kappa
Wirt Rabbit
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