Anti-TRP-1

Anti-TRP-1, Recombinant, IgG2a mOX40 KIH bispecific kappa, Mouse

CloneID: TA99

Heavy Chain modification: Fc Silent™

Antigen Long Description: 70-75 kDa pigmentation-associated glycoprotein in human melanoma cell lines.

Buffer Composition: PBS only.

Chimeric Use Statement: This is a bispecific, knob-into-hole heterodimerized antibody, with one arm directed against TRP-1 (Fab) and one arm directed against mouse OX40 (scFv) based on the antibody clone OX86.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Uniprot Accession No.: P17643

Specificity Statement: Binds Tyrosinase-related protein-1 (TRP-1), a 70-75k enzyme located in melanocytes, which are specialized cells that produce a pigment called melanin, helping to stabilize tyrosinase, which is the enzyme responsible for the first step in melanin production and determine the shape of melanosomes, which are the structures in melanocytes where melanin is produced.

Application Notes (Clone): This antibody binds to human and murine TRP-1 and had been under evaluation for the treatment of tumours.

• Artikelnummer: ABAbAb0182-P
• Hersteller: Absolute Antibody
• Hersteller Artikelnummer: bAb0182-P
• Verpackungseinheit: 50 μg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Recombinant
• Methode: Immunofluorescence, Immunohistochemistry (frozen), Immunoprecipitation, Western Blotting, ELISA, Flow Cytometry
• Isotyp: IgG2a mOX40 KIH bispecific kappa
• Wirt: Mouse