AOH1996, CAS 2089314-64-5

Formulation: A solid

Formal Name: N-[2-[[2-(3-methoxyphenoxy)phenyl]amino]-2-oxoethyl]-1-naphthalenecarboxamide

Purity: ≥98%

Formula Markup: C26H22N2O4

Formula Weight: 426,5

Shelf life (days): 730

CAS Number: 2089314-64-5

Notes: AOH1996 is an inhibitor of proliferating cell nuclear antigen (PCNA).{67493} It binds to PCNA in a thermal shift assay. AOH1996 (500 nM) induces apoptosis in SK-N-DZ neuroblastoma cells but not 7SMOO32 normal neural crest stem cells. It induces DNA damage in SK-N-AS neuroblastoma cells expressing wild-type DNA-directed RNA polymerase II subunit RPB1 but not in SK-N-AS cells expressing RPB1Y418A. AOH1996 (40 mg/kg) decreases tumor volume in SK-N-BE(2)-C neuroblastoma, MDA-MB-468 breast cancer, and NCI H82 small cell lung cancer mouse xenograft models.

• Artikelnummer: CAY39526-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39526-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK