Astemizole, CAS 68844-77-9

Herg channel blocker

Product Type: Inhibitor

CAS No.: 68844-77-9

MolecularFormula: C28H31FN4O

Molecular Weight: 458,57

Source: Synthetic

Purity: >98%

Solubility: Soluble to 100 mM in DMSO and to 25 mM in ethanol

Appearance: White solid

PubChem CID: 2247

Scientific Background: Astemizole is a second generation antihistamine drug which has a long duration of action. It binds to histamine H1-receptor sites in the gastrointestinal tract, uterus, blood vessels and bronchial muscle. It does not cross the blood-brain barrier, and the binding is primarily in the peripheral nervous system (1). It is metabolized by CYP3A4 (2).

References: 1. Laduron P.M., Janssen P.F., Commeren W. and Leysen J.E. (1982) Mol Pharmacol. 21(2): 294-300.2. Maysumoto S., Yamazoe Y. (2001) Br. J Clin Pharamcol. 51(2): 133-142.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-302-50MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-302-50MG
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK