ATF4 Antibody, Clone N360A/24

Mouse Anti-Human ATF4 Monoclonal IgG2a

Target: ATF4

Conjugate: Unconjugated

Product Type: Monoclonal

Clone Number: N360A/24 (Formerly sold as S360A-24)

Immunogen: Fusion protein amino acids 25-327 of human ATF4. 86% identical to rat, and 85% identical to mouse. <50% identity with ATF5.

Swiss-Prot: P18848

Purification: Protein G Purified

Storage Buffer: PBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~60kDa. Does not cross-react with ATF5.

Cellular Localization: Cytoplasm,Cell Membrane,Nucleus

Scientific Background: Cyclic AMP-dependent transcription factor ATF-4 (ATF4) is a basic leucine-zipper (bZip) transcription factor, which regulates amino acid metabolism, DNA damage repair, chromatin remodeling, and apoptosis in response to cellular and ER stress. ATF4 works with various proteins, such as C/EBP homology protein (CHOP), aspargine synthetase (ASNS), and cAMP response element (CRE) among others to mediate cellular stress. ATF4 also regulates glucose homeostasis by suppressing beta-cell proliferation and insulin production. Furthermore, ATF4 targets the histone demethylase JMJD3 to alter chromatin structure and enhance gene transcription in response to amino acid deprivation.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-447D
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-447D
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, Immunohistochemistry, Immunocytochemistry
• Human Gene ID: 468
• Wirt: Mouse