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ATRX antibody (HL1210)
ATRX antibody (HL1210)
Artikelnummer
GTX635478-100
Verpackungseinheit
100 μl
Hersteller
GeneTex
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Clone Name: HL1210
Light Chain: Kappa
Application Note: WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 283
Form: Liquid
Buffer (with preservative): PBS, no preservative.
Concentration: 1.88 mg/ml (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
Uniprot ID: P46100
Antigen Species: Human
Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human ATRX. The exact sequence is proprietary.
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: ATRX chromatin remodeler
Light Chain: Kappa
Application Note: WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 283
Form: Liquid
Buffer (with preservative): PBS, no preservative.
Concentration: 1.88 mg/ml (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
Uniprot ID: P46100
Antigen Species: Human
Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human ATRX. The exact sequence is proprietary.
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: ATRX chromatin remodeler
| Artikelnummer | GTX635478-100 |
|---|---|
| Hersteller | GeneTex |
| Hersteller Artikelnummer | GTX635478-100 |
| Green Labware | Nein |
| Verpackungseinheit | 100 μl |
| Mengeneinheit | STK |
| Reaktivität | Human |
| Klonalität | Monoclonal |
| Methode | Immunofluorescence, Western Blotting, Immunocytochemistry |
| Isotyp | IgG |
| Human Gene ID | 546 |
| Wirt | Rabbit |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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