Target Synonym: AZU1;AZAMP;AZU;CAP37;HBP;HUMAZUR;NAZC;hHBP
Storage: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Background: Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
Buffer: PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Immunogen: Recombinant fusion protein of human AZU1
Dilution: WB 1:500-1:2000
Calculated MW: 26kDa
Observed MW: 35kDa
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