Scientific Background: Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.
References: 1. D'Arcy P., et al. (2011) Nature Medicine 17: 1636.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.