B-Raf (K601E Mutant) antibody

Application Note: WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 84

Form: Liquid

Buffer (with preservative): PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.

Concentration: 0.54 mg/ml (Please refer to the vial label for the specific concentration.)

Background: This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]

Uniprot ID: P15056

Antigen Species: Human

Immunogen: Carrier-protein conjugated synthetic peptide surrounding mutant K601E of human B-Raf. The exact sequence is proprietary.

Purification: Purified by affinity chromatography

Conjugation: Unconjugated

Full Name: B-Raf proto-oncogene, serine/threonine kinase

• Artikelnummer: GTX135414-S-25
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX135414-S-25
• Green Labware: Nein
• Verpackungseinheit: 25 μl
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Immunofluorescence, Western Blotting, Immunocytochemistry
• Isotyp: IgG
• Human Gene ID: 673
• Wirt: Rabbit