BAY-4931, CAS 423150-91-8

Formulation: A solid

Formal Name: 2-chloro-N-[2-(4-ethylphenyl)-5-benzoxazolyl]-5-nitro-benzamide

Purity: ≥98%

Formula Markup: C22H16ClN3O4

Formula Weight: 421,8

Shelf life (days): 1460

CAS Number: 423150-91-8

Notes: BAY-4931 is a PPARγ inverse agonist.{68744} It acts as an inverse agonist in a co-repressor reporter assay with a peptide from nuclear receptor co-repressor 2 (NCOR2; EC50 = 5.8 nM). BAY-4931 selectively induces PPARγ-mediated gene transcription (IC50 = 0.4 nM for the human receptor) over PPARα- or PPARδ-mediated gene transcription in reporter assays using CHO cells (IC50s = >50 µM for both for the human receptors). BAY-4931 inhibits the proliferation of UM-UC-9 human bladder cancer cells that endogenously contain a focal amplification of PPARG, the gene encoding PPARγ (IC50 = 3.4 nM).

• Artikelnummer: CAY40668-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40668-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK