BCMA / Luciferase - CHO Recombinant Cell Line

BCMA / Luciferase - CHO Recombinant Cell Line
Artikelnummer
BPS79724
Verpackungseinheit
2 vials
Hersteller
BPS Bioscience

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Applications: Use as BCMA-expressing target cells in co-culture assays with BCMA CAR T-cells to screen for BCMA-specific cell killing

Background: B-Cell Maturation Antigen (BCMA), also known as CD269, is a cell surface receptor of the TNF receptor superfamily that recognizes B-Cell Activating Factor (BAFF). BCMA is preferentially expressed on mature B-lymphocytes and Multiple Myeloma (MM) cells. BCMA is a highly attractive target antigen for immunotherapy not only because of its restricted expression in non-malignant tissue, but also due to its almost universal expression on MM cells. Pre-clinical studies using CAR (Chimeric Antigen Receptor) T-cells targeting BCMA have demonstrated anti-MM activity, and in 2017, the FDA granted BCMA CAR T-Cell immunotherapy the breakthrough designation in treating Multiple Myeloma.

Description: Recombinant CHO-K1 cells constitutively expressing both the human BCMA protein (B-Cell Maturation Antigen or CD269, GenBank accession #NM_001192) and the firefly luciferase reporter. Surface expression of BCMA was confirmed by flow cytometry.

Host Cell Line: CHO

Mycoplasma Testing: This cell line has been screened using the MycoAlert™ Mycoplasma Detection Kit (Lonza,#LT07-118) to confirm the absence of Mycoplasma contamination. MycoAlert Assay Control Set(Lonza, #LT07-518) was used as a positive control.

Storage Stability: Store in liquid nitrogen immediately upon receipt.

Supplied As: Each vial contains ~ 2 x 10^6 cells in 1 ml of 10% DMSO in FBS.

Warnings: Avoid multiple freeze/thaw cycles.

Biosafety Level: BSL-1
Mehr Informationen
Artikelnummer BPS79724
Hersteller BPS Bioscience
Hersteller Artikelnummer 79724
Verpackungseinheit 2 vials
Mengeneinheit PAK
Wirt Hamster
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