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Bulk anti-Human CD195 (CCR5) antibody (HEK/1/85a/7a)
Bulk anti-Human CD195 (CCR5) antibody (HEK/1/85a/7a), Host: Rat, Rat IgG2b κ
Artikelnummer
ICH1172-100MG
Verpackungseinheit
100mg
Hersteller
Ichorbio
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Target: CD195.
Clone: HEK/1/85a/7a.
Specificity: Clone HEK/1/85a/7a recognizes an epitope on human CCR5.
Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution: CCR5 is expressed on memory T cells, macrophages, and immature dendritic cells (DCs).
Background: CCR5 antibody, HEK/1/85a/7a, recognizes C-C chemokine receptor type 5 (CCR5), also known as CD195, CC-CKR-5, CHEMR13, and HIV-1 fusion coreceptor. CCR5 is a 45 kDa seven-transmembrane G-protein-coupled receptor (GPCR). CCR5 is expressed on a subset of memory T cells, macrophages, and immature dendritic cells (DCs) and is upregulated by proinflammatory cytokines. CCR5 binds to inflammatory CC-chemokines, including CCL3 (macrophage inflammatory protein (MIP)-1α), CCL4 (MIP-1β), and RANTES, which increases intracellular calcium levels and results in cytoskeletal rearrangement and chemotactic cell migration. CCR5 is also the coreceptor for HIV-1 following binding of viral gp120 to CD44-7. The levels of CCR5 on cells influence the rate of entry of HIV-1, and patients with lower levels of CCR5 exhibit immunity against infection. CCR5 also contributes to other human diseases, including type I diabetes and cancer.
Immunogen: CHO cells transfected with full-length human CD195 (CCR5).
Concentration: ≥ 5.0 mg/ml.
Formulation: This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Purity: ≥95% monomer by analytical SEC⋅>95% by SDS Page.
Endotoxin: <1.0 EU/mg as determined by the LAL method.
Aggregation: Aggregation level ≤ 5%.
Use: Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Clone: HEK/1/85a/7a.
Specificity: Clone HEK/1/85a/7a recognizes an epitope on human CCR5.
Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution: CCR5 is expressed on memory T cells, macrophages, and immature dendritic cells (DCs).
Background: CCR5 antibody, HEK/1/85a/7a, recognizes C-C chemokine receptor type 5 (CCR5), also known as CD195, CC-CKR-5, CHEMR13, and HIV-1 fusion coreceptor. CCR5 is a 45 kDa seven-transmembrane G-protein-coupled receptor (GPCR). CCR5 is expressed on a subset of memory T cells, macrophages, and immature dendritic cells (DCs) and is upregulated by proinflammatory cytokines. CCR5 binds to inflammatory CC-chemokines, including CCL3 (macrophage inflammatory protein (MIP)-1α), CCL4 (MIP-1β), and RANTES, which increases intracellular calcium levels and results in cytoskeletal rearrangement and chemotactic cell migration. CCR5 is also the coreceptor for HIV-1 following binding of viral gp120 to CD44-7. The levels of CCR5 on cells influence the rate of entry of HIV-1, and patients with lower levels of CCR5 exhibit immunity against infection. CCR5 also contributes to other human diseases, including type I diabetes and cancer.
Immunogen: CHO cells transfected with full-length human CD195 (CCR5).
Concentration: ≥ 5.0 mg/ml.
Formulation: This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Purity: ≥95% monomer by analytical SEC⋅>95% by SDS Page.
Endotoxin: <1.0 EU/mg as determined by the LAL method.
Aggregation: Aggregation level ≤ 5%.
Use: Products are for research use only. Not for use in diagnostic or therapeutic procedures.
| Artikelnummer | ICH1172-100MG |
|---|---|
| Hersteller | Ichorbio |
| Hersteller Artikelnummer | ICH1172-100MG |
| Green Labware | Nein |
| Verpackungseinheit | 100mg |
| Mengeneinheit | STK |
| Reaktivität | Human |
| Klonalität | Monoclonal |
| Methode | Flow Cytometry, Immunocytochemistry |
| Isotyp | Rat IgG2b κ |
| Wirt | Rat |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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