C-646, CAS 328968-36-1

HAT inhibitor

Product Type: Inhibitor

CAS No.: 328968-36-1

MolecularFormula: C24H19N3O6

Molecular Weight: 445,4

Source: Synthetic

Purity: >98% (TLC), NMR conforms

Solubility: Soluble in 10 mg/ml DMSO

Appearance: Orange Solid

PubChem CID: 1285940

Scientific Background: Potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. Enhances fear extinction memory and synaptic plasticity in mice. Promotes tau deacetylation reducing levels of pathogenic p-tau. Cell permeable.

References: 1. Bowers E.M., et al. (2010) Chem. Biol. 17: 471.2. Santer F.R., et al. (2011) Mol. Cancer Ther. 10: 1644.3. Marek R., et al. (2011) J. Neurosci. 31: 7486.4. Min S.W., et al. (2010) Neuron 67: 953.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-350-25MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-350-25MG
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK