Carnosic acid, CAS 3650-09-7

PPARγ activator

Product Type: Activator

CAS No.: 3650-09-7

MolecularFormula: C20H28O4

Molecular Weight: 332,43

Source: Synthetic

Purity: ≥95% (HPLC); NMR(Conforms)

Solubility: Soluble in DMSO (50 mg/ml)

Appearance: Off white to yellow solid

PubChem CID: 65126

Scientific Background: Carnosic acid is a benzenediol abietane diterpene naturally extracted from rosemary (Rosmarinus officinalis) and sage (Saliva officinalis). It is a potent antioxidant that inhibits NADH or NADPH induced lipid peroxidation by acting as a free radical scavenger (1). It has been found to increase cellular levels of glutathione (GSH) and prevent 6-hydroxydopamine-induced cell death in SH-SY5Y cells (2). Carnosic acid-stimulation of GSH also inhibits adipocyte differentiation (3). It has also been found to induce apoptosis (4) and inhibit the proliferation and migration of various tumor cell lines (5).

References: 1. Schwarz K., Ternes W. (1992) Zeitschrift für Lebensmittel-Untersuchung und –Forschung. 195 (2): 99-103.2. Chen J.H., et al. Chem. (2012) Res. Toxicol 25:1893.3. Takahashi T., et al. (2009) Biochem. Biophys. Res. Commun. 382:549.4. Kar S., et al. (2012) Apoptosis. 17:1735.5. Barni M.V., et al. (2012) Oncol. Rep. 27:1041.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-362-10MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-362-10MG
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK