CavBeta2 Antibody, Clone N8b/1: APC

Mouse Anti-Rat Cav beta 2 Monoclonal IgG1

Target: CavBeta2

Conjugate: APC

Product Type: Monoclonal

Clone Number: N8b/1 (Formerly sold as S8B-1)

Immunogen: Synthetic peptide amino acids 189-205 of rat CavBeta2

Swiss-Prot: Q8VGC3

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~78 kDa. No cross reactivity against Cavβ1, Cavβ3, Cavβ4.

Cellular Localization: Cell Membrane,Sarcolemma

Scientific Background: Cav Beat subunits are involved in the transport of the pore forming alpha1 subunit to the plasma membrane (1). They also shield an ER Retention signal on the alpha1 subunit, thereby guiding the pore-forming subunit to the target membrane (2, 3). They also determine the biophysical properties of the calcium channel (3).

References: 1. Dolphin A.C. (2003) J Bioenerg. Biomembr. 35: 599-620.2. Bichet D., et al. (2000) Neuron. 25: 177-190.3. Xie M., et al. (2007) J Cell Biol. 178(3): 489-502.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-332D-APC
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-332D-APC
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunoprecipitation, Western Blotting, Immunohistochemistry, Immunocytochemistry
• Isotyp: IgG1
• Human Gene ID: 116600
• Wirt: Mouse