CBA, CAS 351424-20-9

TRPM4 channel blocker

Product Type: Blocker

CAS No.: 351424-20-9

MolecularFormula: C15H11Cl2NO4

Molecular Weight: 340,2

Source: Synthetic

Purity: >98% (TLC); NMR (Conforms)

Solubility: May be dissolved in DMSO (35 mg/ml)

Appearance: Off-white powder

PubChem CID: 2264067  

Scientific Background: CBA is a selective blocker of TRPM4 channels (IC50 = 1.5 M) with no activity at TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a panel of other ion channels and receptors (1). Displays protective effects in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration (2). A highly useful tool for exploring the functions of TRM4 in a variety of cell types (3,4).

References: 1.LC Ozhathil et al. Br. J. Pharmacol. 2018 175:25042.B Bianchi et al. Mol. Brain 2018 11:413.A Borgstrom et al. J. Mol. Biol. 2021 433:1666654.G Diszhazi et al. J. Biol. Chem. 2021 297:101015

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-633-5MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-633-5MG
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK