CCT196969, CAS 1163719-56-9

RAF Inhibitor

Product Type: Inhibitor

CAS No.: 1163719-56-9

MolecularFormula: C27H24FN7O3

Molecular Weight: 513,53

Source: Synthetic

Purity: 96%

Solubility: Soluble in DMSO

Appearance: White Solid

Scientific Background: CCT196969, a pan-RAF/SFK inhibitor is active against treatment-naive BRAF and NRAS mutant melanoma tumors. It is also active in tumors from patients who developed resistance to BRAF-selective inhibitors and a BRAF plus MEK inhibitor combination. IC50 0.1µM and 0.03µM for BRAF kinase and SRC kinase respectively.

References: 1. Girotti, M.R., et al. (2015) Cancer Cell 27.1: 85-96.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-185-10MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-185-10MG
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK