CCT241161, CAS 1163719-91-2

RAF Inhibitor

Product Type: Inhibitor

CAS No.: 1163719-91-2

MolecularFormula: C28H27N7O3S

Molecular Weight: 541,63

Source: Synthetic

Purity: 98%

Solubility: Soluble in DMSO

Appearance: White Solid

Scientific Background: CCT241161, a pan-RAF/SFK inhibitor is active against treatment-naive BRAF and NRAS mutant tumors. It is active in tumors from patients who developed resistance to BRAF-selective inhibitors and a BRAF plus MEK inhibitor combination. IC50 0.03µM and 0.01µM for BRAF kinase and SRC kinase respectively.

References: 1. Girotti, M.R., et al. (2015) Cancer Cell 27.1: 85-96.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-186-10MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-186-10MG
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK