CD137, Mouse(LOB12), 1mg/mL

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Description: CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. The LOB12. 3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivo when administered in combination with immune checkpoint inhibitors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Conjugate: Purified, BSA-free

Concentration: 1 mg/mL

Storage buffer: PBS, no BSA, no azide

Product Origin: Animal - Rattus norvegicus (laboratory rat),

Clone: LOB12

Entrez Gene ID: 21942

Immunogen: Murine CD137 human Fc fusion protein

Expected AB Applications: ELISA (published for clone)/Functional studies (published for clone)

Z-Antibody Applications: Functional studies (published)/ELISA (published)

• Artikelnummer: BTMBNUM2012-50
• Hersteller: Biotium
• Hersteller Artikelnummer: BNUM2012-50
• Verpackungseinheit: 50 uL
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Klonalität: Monoclonal
• Methode: ELISA, Functional Studies
• Isotyp: IgG2a kappa
• Wirt: Rat
• Konjugat: Unconjugated