CD155, Fc Fusion, Avi-Tag, Biotin-Labeled Recombinant

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Encompassing Amino Acids: 27-343

Application: Useful for avidin pull down assays.

Background: CD155 (also known as PVR cell adhesion molecule) is a transmembrane glycoprotein receptor of the immunoglobulin superfamily of proteins. It is highly expressed in dendritic cells, fibroblasts, endothelial cells, and multiple tumor cells including ovarian carcinoma, non-small cell lung, glioblastoma, and colorectal carcinoma. It has a high affinity for a T cell regulatory transmembrane surface protein called TIGIT (T cell immunoglobulin and ITIM domains) and plays a key role in tumor cell invasion and migration. Interaction between CD155 and TIGIT causes immunosuppressive effects on CD4⁺ and CD8⁺ T cells, which hinders T cell proliferation and function. CD155 also interacts with the regulatory receptors CD226 (expressed on natural killer (NK) cells, monocytes and CD4⁺ T cells) and CD96. While CD155-CD226 engagement activates NK cell cytotoxicity and T cell response, CD155-CD96 interaction inhibits NK cell function. Due to these opposing regulatory effects, blockade of CD155-TIGIT and CD155- CD226 interactions are attractive therapeutic strategies in cancer immunotherapy and autoimmune diseases, respectively.

Description: Recombinant human CD155, encompassing amino acids 27-343. This construct contains a C-terminal human IgG1 Fc domain followed by an Avi-Tag™. This protein was affinity purified.

Format: Aqueous buffer solution.

Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

Genbank: NM_006505

Host Cell Line: HEK293

Purity: ≥90%

Storage Stability: At least 6 months at -80°C.

Tags: C-terminal Fc, C-terminal Avi-Tag™

Warnings: Avoid freeze/thaw cycles

Biosafety Level: Not applicable (BSL-1)

• Artikelnummer: BPS79064-2
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 79064-2
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Wirt: Human