CD38 antibody (HB7) (PE)

Clone Name: HB7

Light Chain: Kappa

Product Description: The HB7 antibody is specific for human CD38, a 45 kDa type II transmembrane glycoprotein expressed on thymocytes, plasma cells, and monocytes as well as other non-hematopoietic cells. T and B lymphocyte expression is discontinuous and varies based on differentiation state – present on immature cells, low on intermediate stages, and high on activated mature cells. It is found on most CD34+ cells, but not on pluripotent stem cells. CD38 is an ectoenzyme that functions to catalyze the synthesis and hydrolysis of cyclic ADP-ribose and is involved in cell signaling, regulating cell adhesion, and activation. Additionally, CD38 has been shown to be a prognostic marker for some leukemias and other diseases.

Application Note: FACS: 0.125 μg (5 μl) for 10⁵-10⁸ cells in 100 μl sample per test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 34

Form: Liquid

Buffer (with preservative): 10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin, 0.09% Sodium azide.

Concentration: 0.025 mg/ml (Please refer to the vial label for the specific concentration.)

Background: The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Uniprot ID: P28907

Purification: Purified by affinity chromatography

Conjugation: PE

Full Name: CD38 molecule

• Artikelnummer: GTX01499-08-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX01499-08-100
• Green Labware: Nein
• Verpackungseinheit: 100 test
• Mengeneinheit: PAK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Flow Cytometry
• Isotyp: IgG1
• Human Gene ID: 952
• Wirt: Mouse