CD4, Fc Fusion, Avi-Tag, Biotin-Labeled Recombinant

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Encompassing Amino Acids: 26-396

Application: Useful for SDS-PAGE and avidin-pull down assays.

Background: CD4 is a cell surface glycoprotein found on partially defined functional T cell subsets, including helper T cells and T-regulatory cells, peripheral monocytes and other APCs (antigen-presenting cells). The ectodomain of CD4 binds to membrane-proximal domains of MHC (major histocompatibility complex) class II molecules, while its cytoplasmic domains interact with the protein tyrosine kinase p56lck (lck) through a shared cysteine-containing motif. CD4⁺ T cells, or helper T cells, are a type of lymphocyte that helps coordinate the immune response against infection and disease by activating cells of the innate immune system, B-lymphocytes and cytotoxic T cells. CD4⁺ T cells are activated by interaction between the TCR (T- cell receptor) and its cognate peptide presented on MHC II molecules, and CD4 is a critical component of the T cell receptor complex that recognizes antigenic peptides presented by MHC II molecules, increasing its stability. CD4 is typically used as a T cell marker that allows to characterize the populations of T cells present in a sample.

Description: Recombinant human CD4, encompassing amino acids 26-396, corresponding to the extracellular domain. This construct includes an Fc-domain from IgG1 fused at the C-terminus, followed by an Avi-tag™. This protein was affinity purified.

Format: Aqueous buffer solution.

Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

Genbank: NM_000616.5

Host Cell Line: HEK293

Purity: ≥90%

Storage Stability: At least 6 months at -80°C.

Tags: C-Terminal Avi-Tag™

Uniprot: P01730

Warnings: Avoid freeze/thaw cycles

Biosafety Level: Not applicable (BSL-1)

• Artikelnummer: BPS101868-2
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 101868-2
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Wirt: Human