CDC37 Antibody: ATTO 594

Rabbit Anti-Human CDC37 Polyclonal

Target: CDC37

Conjugate: ATTO 594

Product Type: Polyclonal

Immunogen: Native human Cdc37, full length

Swiss-Prot: Q16543

Purification: Protein A Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1.68 mg/ml

Specificity: Detects ~44.5kDa.

Cellular Localization: Cytoplasm

Scientific Background: HSP90 co-chaperone Cdc37 is a protein that is encoded by the CDC37 gene. It has been found to form complexes with HSP90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK and elF-2 alpha kinases. It is thought to play a critical role in directing HSP90 to its target kinases (1, 2). CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multi-targeted therapies (3, 4).

References: 1. Dai K, Kobayashi R., Beach D. (1996) J Biol Chem. 271(36): 22030-22034.2. Stepanova L, Leng X., Parker S.B., Harper J.W. (1996) Genes Dev. 10(12): 1491-1502.3. Kimura Y., et al. (1997) Genes Dev. 11(14): 1775-1185.4. Gray P.J., et al. (2008) Nat Rev Cancer. 8(7): 491-495.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSPC-142D-A594
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SPC-142D-A594
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Immunofluorescence, Western Blotting, Immunocytochemistry
• Human Gene ID: 11140
• Wirt: Rabbit